Designing of novel zincii schiff base complexes having. Hpbh and hacpbh the schiff base ligands hpbh and hacpbh were prepared according to the reported methods 33. Synthesis, characterization and biological studies of some transition metal chelates derived from hydrazone schiff base ligand nandkishor j. Two zincii complexes with similar hydrazone ligands. Schiffbase a germen chemist hugo schiff in 1864 developed a new class of organic compounds. During the past two decades, considerable attention has been paid to the chemistry of the metal complexes of schiff base containing nitrogen and other donors. Crystal structure of salicylaldehyde2,4dinitrophenylhydrazone hassan hosseini monfareda. Synthesis and antibacterial activity of some schiff base. The following are the supplementary data to this article. Schiff base are used as intermediates for the synthesis of amino acids or as ligands for preparation.
Polyfunctional schiff bases are very useful ligands in the synthesis of transition metal complexes. Supplementary information pdf 1878k crystal structure data cif 50k. Pdf synthesis and spectral characterization of hydrazone. Experimental materials and reagents all chemicals used were of analytical reagent grade ar and of the highest purity available.
The schiff base formation is really a sequence of two types of reactions, i. Pdf metal complexes of heterocyclic hydrazone schiffbases. In organic synthesis, schiff base reactions are useful in making carbonnitrogen bonds. Three asymmetric tridentate acyl hydrazone schiff base ligands namely l1. A hydrazone schiff base ligand was synthesized by the condensation of 3formyl4hydroxycoumarin and oxalyldihydrazide in the molar ratio.
New isatinic hydrazone schiffbase ligands, namely furan2carboxylic acid 2oxo1,2dihydroindol3ylidenehydrazide l1, thiophene2carboxylic acid 2oxo1,2dihydroindol3ylidenehydrazide l2 and 2pyridine2ylhydrazono1,2dihydroindol3one l3 are reported. Spectral studies suggested that hydrazone schiff base ligand 1 acts as neutral bidentate ligand n,o. The common schiff base are crystalline solids, which are feebly basic but at least some form insoluble salts with strong acids. Both the ligands and the complexes synthesized are characterized by c, h, n, cl and metal analyses, ir, uvvis, tga, and magnetic susceptibility for tentative structure proposal. Biological activities of schiff bases and their complexes. Schiff bases are generally bi or tridentate ligands capable of forming very stable complexes with transition metals. Synthesis and characterization of metal complexes with.
The tridentate schiff base ligands containing donor ono were prepared by the reaction of 2furaldehyde and urea or thiourea with ethyl acetoacetate to product pyrimidine derivatives 1a, 1b which upon treatment with hydrazine afforded the hydrazide derivatives 2a, 2b the reaction of 2a, ab with 3acetyl coumarin obtained novel schiff base ligands l 1, l 2 in good yield. Nine dioxidomolybdenumvi complexes were synthesized through the reactions of moo 3 with tridentate hydrazone schiff base ligands obtained from the reactions of aromatic acid hydrazides 3. Pdf synthesis, characterization and biological activities of. The complexes of these ligands were synthesized by treating an ethanolic solution of the appropriate ligand and one equivalent et 3 n with an. Nabiya sultana department of studies and research in chemistry, gulbarga university, 585106 gulbarga, karnataka, india. During recent years, aryl hydrazone schiff base ligands, and their transition metal complexes, have attracted more and more attention 1. Synthesis, characterization, thermodynamic and biological activity.
Synthesis, characterization, antimicrobial evaluation and qsar studies of organotiniv complexes of schiff base. Classical cases are the socalled schiffbase couplings. Journal of engineering and applied sciences keywords. Synthesis and spectral characterization of hydrazone schiff base ligand, l derived from condensation of terephthalaldehyde and 2furoic acid hydrazide and its binuclear complexes with coii, ni. They are widely used in different areas, not only because of their facile synthesis, but also for potential biological, catalytic, and. Synthesis, characterization, anticancer and antibacterial. Synthesis, characterization, anticorrosion activity and antibacterial. Request pdf novel ptii complexes with modified aroyl hydrazone schiff base ligands. The schiff base and its complexes have been characterized on the basis of the results of elemental analysis, molar conductance, magnetic susceptibility measurements and spectroscopic studies viz, ftir, 1h nmr, uvvis, mass and epr. Synthesis, characterization, and biological activity of. Synthesis of new schiffbase complexes and their applications. Reactions of fepapy 2 article in inorganic chemistry 4326.
Schiff bases offer a versatile and flexible series of ligand capable of bind with various metal ions to give complexes with suitable properties for theoretical or practical application. Two znii and one mnii complexes using two different. Pdf new isatinic hydrazone schiffbase ligands, namely furan2carboxylic acid 2oxo1,2dihydroindol3ylidenehydrazide l. Nickelii complexes of some quadridentate schiff base. Characterization of complexes synthesized using schiff. Pdf new isatinic hydrazone schiff base ligands, namely furan2carboxylic acid 2oxo1,2dihydroindol3ylidenehydrazide l. Synthesis, characterization and structural studies of co. The ligands experienced keto and enol tautomerization. A pair of new mononuclear zincii complexes with hydrazone ligands 4methoxybenzoic acid 1pyridin2ylmethylidenehydrazide hl a and benzoic acid 1pyridin2ylethylidenehydrazide hl b were prepared. Complexation of these schiff base derivatives with sev eral metal ions showed the capability of forming mono, di and polynuclear metal complexes in which they behaved as monodentate, bidentate or tridentate ligands depending on the positions and number of electron donating groups 1 2 4 5. Preparation, characterization of some transition metal complexes of. It is also reported that hydrazones schiff base and their metal complexes with various transition metals possess antianalgesic, anti inflammation, antibacterial. Thermal and spectral studies on coii, niii and cuii complexes of sulfamethazine schiff base.
Thus provides the possibility synthesis of large number of schiff base complexes with divers structural feature. Synthesis, characterization and biological activities of hydrazone. Synthesis, characterization, anticancer and antibacterial evaluation of schiff base ligands derived from hydrazone and their transition metal complexes. Five dissymmetric tridentate schiff base ligands, containing a mixed donor set of onn and ono were prepared by the reaction of benzhydrazide with the appropriate salicylaldehyde and pyridine2carbaldehyde and characterized by ftir, 1 h and c nmr. Coiii complexes of tridentate schiff base ligands derived from n. In order for undergraduate laboratory experiments to reflect modern research practice, it is essential that they include a range of elements, and that synthetic tasks are accompanied by characterization and analysis. Synthesis, characterization and biological activities of hydrazone schiff base and its novel metals complexes sintesis, pencirian dan aktiviti biologi hidrazon pangkal schiff serta kompleks baru logamnya. Pdf on jul 31, 2019, iqbal hussain and others published synthesis. Epr spectra of metal complexes of schiff base hydrazones were recorded at room temperature on e112 xband spectrometer using tcne as gmarker. The group of compounds, imines are often referred to as schiff bases in his honor.
Synthesis, characterization, antimicrobial evaluation and. Schiff base ligands, coordinating through amide oxygen and the imine nitrogen of hydrazone moiety. The ligands were prepared by the condensation of furan2carboxylic acid hydrazide l1, thiophene2carboxylic. The characteristic bands of the ir spectrum of the schiff base ligand are listed in. New tetradentate schiff base and its coii, niii, cuii. Melting points of the ligands and their metal complexes were determined by open capillary method using sunsim electric melting point apparatus and uncorrected. The infrared spectral data suggested that the hydrazone schiff base behaved as tetradentate ligand with. The two tridentate schiff bases hpbh and hacpbh were prepared by the re. Chemistry and biological importance of schiff bases. Schiff base metal complexes have been known since the mid nineteenth century 27 and even before the general preparation of the schiff base ligands themselves. Synthesis, characterization and biological studies of some.
Schiff bases and their complexes have a variety of applications in biological clinical and analytical fields. The biological activities of synthesized azo schiff base and their metal complexes have been studied for their antibacterial and antifungal activities by well diffusion method, and the stock solution 0. The complexes of these ligands were synthesized by treating an ethanolic solution of the appropriate ligand and one equivalent et 3 n with. Recently there has been a considerable interest in the chemistry of hydrazine and hydrazone compounds because of their potential pharmacological applications. Aswar department of chemistry, sant gadge baba amravati university, amravati444 602. Metal complexes of hydrazones are also recognized for their. All hydrazone schiff base ligands12 and their metal complexes 38 are nonelectrolyte in nature. The compound ligands exhibited a variable activity of inhibition. Schiff base metal complexes have occupied a central place in the development of coordination chemistry after the work of jorgensen and werner 28. Faculty of resource science and technology synthesis and. Metal complexes of heterocyclic hydrazone schiffbases. Potentiometric and thermodynamic studies of schiff base. Schiff base, magnetic susceptibility and thermal introduction the hydrazone schiff bases are widely used ligands to synthesize their metal complexes due to their facile synthesis, significant and good solubility in common organic solvents.
Find, read and cite all the research you need on researchgate. Synthesis and spectral characterization of hydrazone. Schiff base ligands have significant importance in chemistry. All hydrazone schiff base ligands 12 and their metal complexes 38 are nonelectrolyte in nature. Pdf metal complexes of heterocyclic hydrazone schiff. The complexes were characterized by physicochemical methods and single crystal xray determination. Coordination complexes with metal ions cuii, niii, coii, feiii, mnii, criii, and voii with six ligands formed by condensation products using azides and aldehydes or ketones are characterized. Synthesis, crystal structure and electrochemical studies of a hydrazone schiff base complex of titaniumiv hassan hosseini monfareda, majid nazaria, peter mayerb, mohammadalikamyabia, andrea erxlebenc, and zohre asgaria a department of chemistry, faculty of sciences, zanjan university 451953, zanjan, i. They can contain additional donor atoms like oxygen, sulphur, nitrogen etc. Synthesis and spectral characterization of hydrazone schiff bases. Schiff bases have a large number of synthetic uses in organic chemistry. Synthesis, structural, and biological studies of some. The two schiff base ligands were prepared based on the literature 44,45. Synthesis and characterization of some transition metal.
A potential method for onepot synthesis of schiff base compounds derived from different aldehyde and diamine compounds like substituted aromatic aldehyde and diamines. The electrochemical synthesis of neutral complexes with asymmetric n2so tetradentate schiffbase ligands. Synthesis and spectral characterization of hydrazone schiff bases derived from 2,4dinitrophenylhydrazine. Synthesis and charactherization of transition metal. Synthesis, crystal structure and electrochemical studies. Chanda1 1department of biosciences and 2department of chemistry, saurashtra university, rajkot 360 005, gujarat, india email. Synthesis and characterization of schiff base metal. In this work, we report the results of our studies on the synthesis and spectral properties. Synthesis, characterization and biological activities of.